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Table 4 Constrained model fits to the human influenza infection data in Figure 6.

From: Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture

A/Texas/36/91 (H1N1) [38]

Dista

c (h鈥�1)

p b,c

蟿 L (h)

蟽 L

蟿 I (h)

蟽 I

(h)

(h)

R 0

SSRd

exp

0.19

0.022

280

5.4

鈥�

16.9

鈥�

3.7

11.7

89

1.00

未

0.059

2.85

62

10.2

鈥�

23.0

鈥�

10.2

23.0

390

1.00

N

0.059

0.013

100

1.8

(4.6 h)c

12.1

(9.7 h)

3.9

13.4

240

0.98

lnN

0.059

0.72

99

8.7

(0.49)

14.5

(0)

8.7

14.5

250

1.00

A/Bethesda/1/85 (H3N2) [39]

Dist

c (h鈥�1)

V 0

p

蟿 L (h)

蟽 L

蟿 I (h)

蟽 I

(h)

(h)

R 0

SSR

exp

0.11

7.0

1.3 脳 105

9.0

鈥�

2.2

鈥�

6.4

1.5

20

0.91

未

0.10

28.4

7.7 脳 103

9.9

鈥�

31.5

鈥�

9.9

31.5

320

0.88

N

0.10

10.6

1.2 脳 104

9.6

(4.6 h)

19.9

(9.7 h)

9.7

20.1

200

0.90

lnN

0.10

11.8

8.0 脳 103

8.5

(0.49)

30.4

(0)

8.5

30.4

300

0.91

  1. a 鈥� Delay model used: exponential (exp), fixed (未), normal (N), and lognormal (lnN).
  2. b 鈥� Units of p are [V闭路丑鈥�1, where [V] = TCID50/mL, the units of viral titer.
  3. c 鈥� The value of 辫尾 was held fixed at 1 h鈥�2 for all fits; values in parentheses were also eld fixed.
  4. d 鈥� SSR鈥� is the ratio of the SSR to that of the empirical fit.
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