Risk variables | Category | Unvaccinated | Vaccinated | P value | ||
---|---|---|---|---|---|---|
n | % | N | % | |||
Number of patients, n (%) | Controls | 4872 | 75.5 | 1556 | 77.7 | 0.042 |
Cases | 1581 | 24.5 | 446 | 22.3 | ||
Age (y) | Median (range) | 14.6 (0.8-84.0) | 78.7 (9.0-91.9) | <0.001 | ||
Age group, n (%) | 6–11 mo | 496 | 7.7 | 3 | 0.1 | |
1–4 y | 2120 | 32.9 | 49 | 2.4 | ||
5–17 y | 712 | 11.0 | 102 | 5.1 | ||
18–49 y | 1347 | 20.9 | 75 | 3.7 | ||
50–64 y | 591 | 9.2 | 138 | 6.9 | ||
65–74 y | 388 | 6.0 | 416 | 20.8 | ||
75–84 y | 512 | 7.9 | 704 | 35.2 | ||
≥85 y | 287 | 4.4 | 515 | 25.7 | ||
Female, n (%) | - | 2825 | 43.8 | 843 | 42.1 | 0.188 |
Comorbidities, n (%) | None | 4505 | 70 | 366 | 18.3 | <0.001 |
1 | 1077 | 16.7 | 647 | 32.3 | ||
>1 | 871 | 13.5 | 989 | 49.4 | ||
Pregnant, n (%) | - | 294 | 4.6 | 3 | 0.1 | <0.001 |
Obesity, n (%) | - | 982 | 15.2 | 564 | 28.2 | <0.001 |
Morbid obesity, n (%) | - | 86 | 1.3 | 54 | 2.7 | <0.001 |
Previous hospitalisation within 12months, n (%) | - | 1887 | 29.2 | 761 | 38 | <0.001 |
GP visit within 3months, n (%) | None | 1815 | 28.1 | 343 | 17.1 | <0.001 |
1 | 2027 | 31.4 | 389 | 19.4 | ||
>1 | 2606 | 40.4 | 1272 | 63.5 | ||
Smoking, n (%) | Current | 1527 | 23.7 | 225 | 11.2 | <0.001 |
Past | 1069 | 16.6 | 742 | 37.1 | ||
Never | 3856 | 59.8 | 1035 | 51.7 | ||
Functional impairment in ≥65 y, n (%) | None or minimal | 619 | 54.2 | 1021 | 62.4 | <0.001 |
Mild | 324 | 28.4 | 330 | 20.2 | ||
Moderate | 95 | 8.3 | 88 | 5.4 | ||
Severe | 32 | 2.8 | 62 | 3.8 | ||
Total | 72 | 6.3 | 123 | 7.5 | ||
Sampling interval (days) | Median (range) | 3 (1-7) | 4(1-7) | <0.001 | ||
Sampling interval, n (%) | ≤4 d | 3703 | 57.4 | 990 | 49.5 | <0.001 |
5-7 d | 2587 | 40.1 | 936 | 46.8 | ||
8-9 d | 163 | 2.5 | 76 | 3.8 | ||
Site, n (%) | St. Petersburg | 2138 | 33.1 | 59 | 2.9 | <0.001 |
Moscow | 1306 | 20.2 | 39 | 1.9 | ||
Turkey | 503 | 7.8 | 26 | 1.3 | ||
Beijing | 996 | 15.4 | 127 | 6.3 | ||
Valencia | 1510 | 23.4 | 1751 | 87.5 | ||
Vaccinated, n (%) | ||||||
In 2012–2013 | 473 | 7.5 | 1471 | 73.3 | <0.001 | |
In 2013–2014 | 513 | 8.1 | 1722 | 87.1 | <0.001 |