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Table 1 Multivariate analysis for factors associated with antibiotic over-prescription for diarrheal children under 5 years old without dysentery in Asembo (N = 2685)

From: Inappropriate use of antibiotics for childhood diarrhea case management — Kenya, 2009–2016

Factors

Antibiotic prescribed (%)

Antibiotic not prescribed (%)

Crude odds ratio (95% CI)

Adjustedb odds ratio (95% CI)

Demographics

ÌýÌýÌýÌý

â€Çã²µ±ð &±ô³Ù; 1

545/1410 (38.3%)

408 /1275 (32.0%)

1.32 (1.13–1.55)

Ìý

 M²¹±ô±ð

745/1410 (52.8%)

707/1275 (55.5%)

1.11 (0.95–1.29)

Ìý

Recent medical history

 Clinic visit within 14 days

182/1410 (12.9%)

127/1275 (10.0%)

1.34 (1.05–1.70)

Ìý

 Clinic visit within 14 days with diarrheal symptom

43/1406 (3.1%)

25/1270 (2.0%)

1.57 (0.95–2.59)

Ìý

 Clinic visit within 14 days with antibiotic treatment

64/1410 (4.5%)

42/1275 (3.3%)

1.40 (0.94–2.08)

Ìý

Signs and symptoms

 W±ð¾±²µ³ó³Ù-´Ú´Ç°ù-²¹²µ±ð &±ô³Ù; −2

263/1395 (18.9%)

254/1262 (20.1%)

0.92 (0.76–1.12)

Ìý

‽ö±ð¾±²µ³ó³Ù-´Ú´Ç°ù-²¹²µ±ð &±ô³Ù; −2

369/1320 (28.0%)

324/1201 (27.0%)

1.05 (0.88–1.25)

Ìý

 W±ð¾±²µ³ó³Ù-´Ú´Ç°ù-³ó±ð¾±²µ³ó³Ù &±ô³Ù; −2

182/1302 (14.0%)

182/1181 (15.4%)

0.89 (0.71–1.11)

Ìý

 Measured or reported fever

1158/1410 (82.1%)

1112/1275 (87.2%)

0.67 (0.54–0.83)

Ìý

 C´Ç³Ü²µ³ó

691/1410 (49.0%)

601/1275 (47.1%)

1.08 (0.93–1.25)

Ìý

 Difficulty breathing

12/1409 (0.9%)

11/1274 (0.9%)

0.99 (0.43–2.24)

Ìý

 Sore throat

12/1358 (0.9%)

4/1266 (0.3%)

2.81 (0.90–8.72)

5.03 (0.73–34.91)

 V´Ç³¾¾±³Ù¾±²Ô²µ

469/1410 (33.3%)

462/1272 (36.3%)

0.87 (0.75–1.03)

0.79 (0.58–1.07)

 Runny nose

477/1410 (33.8%)

416/1275 (32.6%)

1.06 (0.90–1.24)

Ìý

â€ÇȲԱð±ð³ú¾±²Ô²µ

251/1409 (17.8%)

202/1275 (15.8%)

1.15 (0.94–1.41)

Ìý

Physical examination

 Restless or irritable

80/1409 (5.7%)

46/1270 (3.6%)

1.60 (1.11–2.32)

1.39 (0.81–2.40)

 Sunken eyes

128/1408 (9.1%)

78/1270 (6.1%)

1.53 (1.14–2.05)

1.22 (0.80–1.84)

 Drinks eagerly, thirsty

58/1407 (4.1%)

36/1268 (2.8%)

1.47 (0.96–2.25)

Ìý

 Skin tenting

87/1405 (6.2%)

46/1270 (3.6%)

1.76 (1.22–2.53)

Ìý

 Signs of anemia

30/1378 (2.2%)

36/1243 (2.9%)

0.75 (0.46–1.22)

Ìý

 C°ù²¹³¦°ì±ô±ð²õ/°ù²¹±ô±ð²õ

3/1408 (0.2%)

6/1272 (0.5%)

0.45 (0.11–1.81)

Ìý

Clinical diagnoses

 G²¹²õ³Ù°ù´Ç±ð²Ô³Ù±ð°ù¾±³Ù¾±²õ

1292/1410 (91.6%)

792/1275 (62.1%)

6.68 (5.36–8.32)

8.23 (3.68–18.40)

 M²¹±ô²¹°ù¾±²¹

322/1410 (22.8%)

660/1275 (51.8%)

0.27 (0.23–0.33)

0.37 (0.25–0.54)

 D±ð³ó²â»å°ù²¹³Ù¾±´Ç²Ô

123/1410 (8.7%)

66/1275 (5.2%)

1.75 (1.28–2.39)

Ìý

 U¸é°Õ±õa

415/1410 (29.4%)

352/1275 (27.6%)

1.09 (0.93–1.29)

Ìý

Prescription

 Concurrent ORSa

1130/1410 (80.1%)

830/1275 (65.1%)

2.16 (1.82–2.58)

0.49 (0.33–0.71)

 Concurrent zinc

765/1410 (54.3%)

714/1275 (56.0%)

0.93 (0.80–1.09)

Ìý
  1. aURTI Upper respiratory tract infection, ORS Oral rehydration solution
  2. bAdjusted by variables shown with adjusted OR and within-clinician variation
  3. Odd ratio in bold indicates p-value < 0.05