Psycho-social dimensions of cardiovascular risk: exploring the impact of social isolation and loneliness in middle-aged and older adults

Table 3 Mediation analysis of inflammation score in the association of social isolation, loneliness and incident cardiovascular disease (Page 12)

听	Total effect size	Direct effect		Indirect effect		P-value
听	Total effect size	Size	Proportion	Size	Proportion	P-value
Social isolation 鈫� Inflammation score 鈫� Stroke	0.0011	0.0009	86.4823%	0.0002	13.5177%	0.22
Loneliness 鈫� Inflammation score 鈫� Stroke	0.0020	0.0019	95.1268%	0.0001	4.8732%	&濒迟;鈥�0.01
Social isolation 鈫� Inflammation score 鈫� Myocardial infarction	0.0011	0.0007	71.0005%	0.0004	28.9995%	0.20
Loneliness 鈫� Inflammation score 鈫� Myocardial infarction	0.0052	0.0050	95.3255%	0.0002	4.6745%	&濒迟;鈥�0.01
Social isolation 鈫� Inflammation score 鈫� CVD	0.0018	0.0012	72.0037%	0.0006	27.9963%	0.14
Loneliness 鈫� Inflammation score 鈫� CVD	0.0071	0.0068	95.3320%	0.0003	4.6680%	&濒迟;鈥�0.01

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