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Age, years

44.6 (44.1–45.1)

45.4 (44.9–45.9)

45.6 (45.1–46.1)

47.8 (47.2–48.4)

52.0 (51.2–52.8)

Male, %

73.0 (71.9–74.0)

59.2 (58.2–60.2)

43.4 (42.0−44.7)

29.8 (28.6–31.0)

20.1 (18.5–21.9)

Ethnicity, %

Non-Hispanic White

68.6 (66.0–71.0)

66.7 (64.5–68.9)

67.2 (64.9–69.6)

70.1 (67.9–72.1)

74.1 (71.5–76.4)

Non-Hispanic Black

7.5 (6.6–8.5)

10.2 (9.2–11.3)

11.9 (10.7–13.3)

12.2 (10.9–13.6)

13.5 (11.8–15.4)

Hispanic

16.7 (14.8–18.8)

16.2 (14.5–18.2)

13.7 (12.3–15.4)

11.1 (9.9–12.4)

6.6 (5.6–7.7)

Other

7.2 (6.4–8.1)

6.9 (6.2–7.6)

7.1 (6.3−8.0)

6.6 (5.9–7.4)

5.9 (4.9−7.0)

Body mass index, kg/m²

31.3 (31.0−31.5)

29.9 (29.8–30.1)

28.2 (28.1–28.4)

26.4 (26.2–26.5)

24.7 (24.5–25.0)

Systolic blood pressure, mmHg

124 (123–124)

123 (123–124)

122 (122–123)

122 (122–123)

125 (124–126)

Smoking status, %

Never smoker

48.5 (47.1–50.0)

54.4 (52.9–55.9)

57.7 (56.4–59.1)

59.9 (58.6–61.2)

55.5 (53.2–57.7)

Former smoker

23.7 (22.6–24.9)

23.4 (22.3–24.5)

23.6 (22.5–24.7)

23.3 (22.2–24.5)

26.1 (24.0−28.3)

Current smoker

27.8 (26.3–29.2)

22.2 (21.2–23.3)

18.7 (17.7–19.8)

16.7 (15.9–17.6)

18.4 (16.6–20.4)

Alcohol consumption*, %

Never

39.5 (38.1–41.0)

37.9 (36.3–39.4)

37.4 (35.8–38.9)

35.0 (33.7–36.3)

32.0 (29.9–34.2)

Less than once a week

57.6 (56.1–59.2)

58.9 (57.4–60.5)

58.9 (57.3–60.5)

60.3 (59.0−61.6)

63.4 (61.0−65.8)

More than once a week

2.8 (2.2–3.6)

3.2 (2.8–3.7)

3.7 (3.1–4.4)

4.7 (3.7–5.8)

4.6 (3.4–6.1)

Cumulative times of alcohol consumption, per year

8.2 (7.0−9.4)

8.4 (7.5–9.4)

8.5 (7.4–9.5)

10.3 (9.1–11.5)

11.2 (8.6–13.7)

LDL cholesterol, mgl/dL

112 (110–113)

117 (116–117)

115 (114–116)

111 (110–112)

107 (105–109)

Triglycerides, mgl/dL

247 (241–253)

157 (154–160)

123 (122–125)

100 (98–102)

84 (82–86)

Fasting status†, %

(48.3–51.4)

54.6 (53.4–55.8)

55.1 (53.8–56.4)

55.2 (53.8–56.5)

54.4 (51.9–56.9)

Diabetes mellitus, %

13.3 (12.4–14.2)

10.5 (9.8–11.2)

7.1 (6.6–7.7)

5.4 (4.9−6.0)

3.7 (3.0−4.5)

Coronary artery disease, %

4.9 (4.4–5.5)

4.0 (3.5–4.5)

2.8 (2.5–3.2)

2.2 (1.8–2.6)

2.3 (1.8–3.1)

Stroke, %

3.2 (2.8–3.7)

2.8 (2.5–3.1)

2.5 (2.2–2.8)

2.3 (2.0−2.7)

2.9 (2.2–3.8)

Heart failure, %

3.6 (3.1–4.1)

2.4 (2.2–2.7)

1.9 (1.6–2.2)

1.7 (1.4−2.0)

1.7 (1.3–2.3)

COPD, %

6.6 (5.9–7.5)

5.8 (5.3–6.3)

5.4 (4.8–6.1)

5.4 (4.8−6.0)

7.3 (6.1–8.5)

Cancer, %

7.9 (7.2–8.7)

8.9 (8.3–9.6)

8.5 (7.9–9.3)

9.7 (9.0−10.4)

13.1 (11.6–14.6)

Chronic renal disease (eGFR < 60Ìýml/min), %

6.3 (5.8–6.8)

6.4 (6.0−6.9)

6.2 (5.7–6.7)

6.3 (5.8–6.8)

7.3 (6.0−8.9)

Aspirin use, %

9.1 (8.1–10.2)

8.7 (8.0−9.6)

8.1 (7.4–8.8)

8.7 (7.9–9.7)

9.8 (8.0−12.1)

Statin use, %

15.8 (14.7–17.0)

15.5 (14.7–16.4)

14.2 (13.3–15.2)

12.9 (12.0−13.8)

12.2 (10.6–14.0)

Education level, %

Under high school

20.6 (19.5–21.8)

18.3 (17.2–19.5)

15.9 (14.8–17.1)

13.4 (12.5–14.4)

11.9 (10.5–13.5)

High school graduate

26.3 (24.9–27.7)

24.6 (23.6–25.6)

22.6 (21.4–23.9)

20.4 (19.2–21.5)

20.6 (18.7–22.7)

Above high school/unknown

53.1 (51.3–54.9)

57.1 (55.6–58.6)

61.5 (59.8–63.1)

66.2 (64.6–67.8)

67.4 (64.9–69.9)

Marital status, %

Married/cohabiting

64.3 (62.6–65.9)

61.9 (60.7–63.0)

60.1 (58.7–61.5)

58.7 (57.1–60.2)

59.4 (57.1–61.7

Separated/divorced/widowed

14.6 (13.7–15.6)

16.3 (15.5–17.0)

17.7 (16.8–18.7)

20.7 (19.6–21.7)

24.5 (22.7–26.4)

Never married/unkown

21.1 (19.5–22.8)

21.9 (20.6–23.1)

22.2 (20.9–23.5)

20.7 (19.2–22.3)

16.1 (14.5–17.8)

Poverty income ratio (PIR)#

2.8 (2.7–2.8)

2.9 (2.8−3.0)

3.0 (2.9–3.1)

3.2 (3.1–3.2)

3.4 (3.3–3.5)

All-cause mortality, %

12.3 (11.5–13.2)

10.9 (10.3–11.6)

9.5 (8.7–10.2)

10.4 (9.6–11.2)

13.4 (12.0−14.8)

CVD mortality, %

3.8 (3.4–4.3)

3.2 (2.9–3.6)

2.8 (2.5–3.2)

3.1 (2.7–3.5)

3.5 (2.9–4.1)

Non-CVD mortality, %

8.5 (7.8–9.1)

7.7 (7.2–8.2)

6.7 (6.1–7.3)

7.3 (6.7–7.9)

9.9 (8.7–11.1)