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Table 2 Characteristics of studies included in meta-analysis

From: Impact of ultra-processed foods consumption on the burden of obesity and type 2 diabetes in Belgium: a comparative risk assessment

Author

(year)

Country

Cohort study & follow-up

Characteristics of participants

UPF survey

Diagnoses of DM

Analysis method

RR or HR (95% CI)

Covariates adjusted

Type 2 diabetes mellitus

 C³ó±ð²Ô et al. (2023) [29]

United States

NHS

(32 years)

71 871 women aged 30–55 years

Self-administered 130-items semi-quantitative FFQ, every 2–4 years

Self-reports by participants identified through follow-up questionnaires and confirmed by a validated supplementary questionnaire

Cox proportional hazards regression

Quintiles: Q1 (Reference)

Q2 HR: 1.06 (95%CI 0.98–1.15)

Q3 HR: 1.17 (95%CI 1.08–1.26)

Q4 HR: 1.27 (95%CI 1.18–1.37).

Q5 HR: 1.36 (95%CI 1.26–1.46)

For each 10%

HR 1.13 (95% CI 1.11–1.15)

Age, race, family history of diabetes, history of hypercholesterolemia at baseline, history of hypertension at baseline, baseline BMI, smoking status, physical activity, oral contraceptive use, postmenopausal hormone use, physical examination in the past 2 years, neighborhood income, total alcohol consumption, and total energy intake

 C³ó±ð²Ô et al. (2023) [29]

United States

NHSII

(26 years)

87 918 women aged 25–44 years

Self-administered 130-items semi-quantitative FFQ, every 2–4 years

Self-reports by participants identified through follow-up questionnaires and confirmed by a validated supplementary questionnaire

Cox proportional hazards regression

Quintiles: Q1 (Reference)

Q2 HR: 1.23 (95% 1.12–1.34).

Q3 HR: 1.33 (95%CI 1.22–1.45)

Q4 HR:1.37 (95%CI1.26-1.50)

Q5 HR:1.63 (95%CI1.50-1.76

For each 10%

HR 1.11 (95%CI 1.09–1.13)

Age, race/ethnicity, family history of diabetes, history of hypercholesterolemia at baseline, history of hypertension at baseline, baseline BMI, smoking status, physical activity, postmenopausal hormone use, oral contraceptive use, physical examination, neighborhood income, total alcohol consumption, and total energy

 C³ó±ð²Ô et al. (2023) [29]

United States

HPFS

(30 years)

38 847 men aged 40–75 years

Self-administered 130-items semi-quantitative FFQ, every 2–4 years

Self-reports by participants identified through follow-up questionnaires and confirmed by a validated supplementary questionnaire

Cox proportional hazards regression

Quintiles: Q1 (Reference)

Q2 HR:1.08 (95%CI 0.96–1.21). Q3 HR: 1.16 (95%CI 1.04–1.30). Q4 HR: 1.22 (95%CI 1.09–1.37). Q5 HR:1.41 (95%CI 1.26–1.58)

For each 10%

HR 1.09 (95%CI 1.06, 1.13)

Age, race/ethnicity, family history of diabetes, history of hypercholesterolemia at baseline, history of hypertension at baseline, baseline BMI, smoking status, physical activity, physical examination, neighborhood income, total alcohol consumption, and total energy

 L±ð±¹²â et al. (2021) [30]

UK

UK Biobank

(5.4 years)

21 730 participants aged 40–79 years, 52.9% were women

Web-based, self-administered questionnaire in the previous 24 hours at baseline and within 3 years after

Self-report and nurse-interview data.

Derived an algorithm

to identify people with or without incident type 2 diabetes

Cox proportional hazards regression

Quartiles: Q1 (Reference)

Q2 HR: 0.98 (95%CI 0.68–1.39)

Q3 HR: 1.10 (95% CI 0.76–1.55) Q4 HR: 1.44 (95%CI 1.04–2.02)

For each 10%

HR 1.12 (95%CI 1.04–1.20)

Age, family history of diabetes, sex, ethnicity, Index of Multiple Deprivation, physical activity level, current smoking status,total energy intake, BMI at baseline

â€ÇȰù´Ç³Ü°ù et al. (2020) [31]

France

Nutrinet Santé

(6.0 years)

104 707 participants aged more than 18 years, 79.2% were women

3 non-consecutive

validated web-based 24-hour dietary records at

baseline and every 6 months,

randomly assigned over a 2-week period (2 weekdays

and 1 weekend day)

Self-questionnaires linked to medical databases of the SNIIRAM

Cox proportional hazards regression

For each 10%

HR 1.15 (95%CI 1.06–1.25)

Age, sex, educational level, baseline BMI, physical activity level, smoking status, alcohol intake, number of 24-hour dietary records, energy intake without alcohol, family history of diabetes, overall nutritional quality of the diet, number of 24-hour dietary records, energy intake, FSAm-NPS DI score, and family history of type 2 diabetes

Obesity

 R²¹³Ü²ú±ð°ù et al.

(2021) [32]

England, Scotland and Wales

UK Biobank

(5.0 years)

22 659 participants aged 40–69 years and 52.1% were women

Web-based 24-hour dietary records at the end of the recruitment

between the next two years (4 times).

BMI at baseline and follow-up.

Cox proportional hazards regression

Quartiles: Q1 (Reference)

Q2 HR: 1.21 (95%CI 1.00–1.47)

Q3 HR: 1.17 (95%CI 0.97–1.42)

Q4 HR: 1.62 (95%CI 1.35–1.94).

For each 10%

HR:1.11 (95%CI 1.07–1.15)

Sex, Index of Multiple Deprivation, physical activity, smoking status, sleep duration, BMI at baseline

 C²¹²Ô³ó²¹»å²¹ et al.

(2017) [33]

Brazil

ELSA-Brasil

(3.8 years)

11 827 participants aged 35–74 years, and 55% were women

FFQ at baseline. (Evaluate diet in the last 12 months).

The annual weight gain in BMI.

At baseline and after a mean 3.8 years

Poisson regression

Quartiles: Q1 (Reference)

Q2 RR: 1.12 (95%CI 0.92–1.35)

Q3 RR 1.03 (95% CI 0.85–1.26)

Q4 RR 1.11 (95%CI 0.91–1.36)

For each 15%

RR 1.13 (95%CI 1.01–1.26)

Age, sex, race, centre, income, school achievement, smoking, and physical activity

  1. Abbreviations: NHS Nurses’ Health Study, NHSII Nurses’ Health Study II, HPFS Health Professional Follow-Up Study, RR Relative risk, HR Hazard ratio, FFQ Food Frequency Questionnaire, BMI Body Mass Index, FSAm-NPS DI score Nutrient Profiling System of the British Food Standards Agency Dietary Index Score, ELSA-Brasil Brazilian Longitudinal Study of Adult Health Cohort