Characteristics | Total (n = 90,258) | Body mass index change (kg/m2) n (%)†| P value | ||||
---|---|---|---|---|---|---|---|
&±ô³Ù;−10% | <−5% to − 10% | −5% to + 5% | >+5% to < + 10% | ≥+10% | |||
(n = 1,525) | (n = 6,197) | (n = 63,233) | (n = 14,103) | (n = 5,200) | |||
Clinical and demographic characteristics | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
Age, years | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 M±ð²¹²Ô ±â¶Ä‰S¶Ù | 42.0 ±â¶Ä‰11.6 | 41.0 ±â¶Ä‰12.4 | 43.4 ±â¶Ä‰12.6 | 42.8 ±â¶Ä‰11.6 | 39.9 ±â¶Ä‰10.5 | 37.0 ±â¶Ä‰9.4 | &±ô³Ù; 0.001 |
 18–49 | 43,983 (48.7) | 832 (54.6) | 2785 (44.9) | 28,788 (45.5) | 7972 (56.5) | 3606 (69.4) | &±ô³Ù; 0.001 |
 ≥50 | 46,275 (51.3) | 693 (45.4) | 3412 (55.1) | 34,445 (54.5) | 6131 (43.5) | 1594 (30.7) | Ìý |
Birth cohort | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 &±ô³Ù;1940 | 3201 (3.6) | 70 (4.6) | 289 (4.7) | 2431 (3.8) | 332 (2.4) | 79 (1.5) | &±ô³Ù; 0.001 |
 1940–1949 | 7276 (8.1) | 100 (6.6) | 678 (10.9) | 5642 (8.9) | 706 (5.0) | 150 (2.9) | Ìý |
 1950–1959 | 14,384 (15.9) | 221 (14.5) | 1160 (18.7) | 11,056 (17.5) | 1613 (11.4) | 334 (6.4) | Ìý |
 1960–1969 | 29,072 (32.2) | 426 (27.9) | 1734 (28.0) | 20,808 (32.9) | 4709 (33.4) | 1395 (26.8) | Ìý |
 1970–1979 | 31,187 (34.6) | 559 (36.7) | 1886 (30.4) | 20,184 (31.9) | 5845 (41.5) | 2713 (52.2) | Ìý |
 ≥ 1980 | 5138 (5.7) | 149 (9.8) | 450 (7.3) | 3112 (4.9) | 898 (6.4) | 529 (10.2) | Ìý |
Sex | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 F±ð³¾²¹±ô±ð | 44,394 (49.2) | 908 (59.5) | 3394 (54.8) | 29,843 (47.2) | 7310 (51.8) | 2939 (56.5) | &±ô³Ù; 0.001 |
 M²¹±ô±ð | 45,864 (50.8) | 617 (40.5) | 2803 (45.2) | 33,390 (52.8) | 6793 (48.2) | 2261 (43.5) | Ìý |
BMI group (kg/m2) at the first health screening | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 Normal (18.5–23.9) | 51,457 (57.0) | 583 (38.2) | 3262 (52.6) | 35,572 (56.3) | 8670 (61.5) | 3370 (64.8) | &±ô³Ù; 0.001 |
 Underweight (< 18.5) | 8020 (8.9) | 22 (1.4) | 240 (3.9) | 5140 (8.1) | 1773 (12.6) | 845 (16.3) | Ìý |
 Overweight (24–26.9) | 20,545 (22.8) | 445 (29.2) | 1719 (27.7) | 15,210 (24.1) | 2497 (17.7) | 674 (12.9) | Ìý |
 Obese (≥ 27) | 10,236 (11.3) | 475 (31.2) | 976 (15.8) | 7311 (11.6) | 1163 (8.3) | 311 (6.0) | Ìý |
BMI group (kg/m2) at the last health screening | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 Normal (18.5–23.9) | 50,339 (55.8) | 943 (61.8) | 3960 (63.9) | 35,299 (55.8) | 7667 (54.4) | 2470 (47.5) | &±ô³Ù; 0.001 |
 Underweight (< 18.5) | 6404 (7.1) | 216 (14.2) | 721 (11.6) | 4782 (7.6) | 579 (4.1) | 106 (2.0) | Ìý |
 Overweight (24–26.9) | 21,829 (24.2) | 239 (15.7) | 1074 (17.3) | 15,443 (24.4) | 3572 (25.3) | 1501 (28.9) | Ìý |
 Obese (≥ 27) | 11,686 (13.0) | 127 (8.3) | 442 (7.1) | 7709 (12.2) | 2285 (16.2) | 1123 (21.6) | Ìý |
Level of education | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 Junior high school or less | 10,904 (12.1) | 199 (13.1) | 974 (15.7) | 8204 (13.0) | 1237 (8.8) | 290 (5.6) | &±ô³Ù; 0.001 |
 Senior high school | 38,920 (43.1) | 677 (44.4) | 2579 (41.6) | 27,007 (42.7) | 6255 (44.4) | 2402 (46.2) | Ìý |
 University or higher | 40,434 (44.8) | 649 (42.6) | 2644 (42.7) | 28,022 (44.3) | 6611 (46.9) | 2508 (48.2) | Ìý |
Marital status | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 N±ð±¹±ð°ù married | 19,535 (21.6) | 425 (27.9) | 1350 (21.8) | 12,725 (20.1) | 3492 (24.8) | 1543 (29.7) | &±ô³Ù; 0.001 |
 M²¹°ù°ù¾±±ð»å/³¦´Ç³ó²¹²ú¾±³Ù¾±²Ô²µ | 65,266 (72.3) | 983 (64.5) | 4366 (70.5) | 46,661 (73.8) | 9834 (69.7) | 3422 (65.8) | Ìý |
 O³Ù³ó±ð°ù†| 5457 (6.1) | 117 (7.7) | 481 (7.8) | 3847 (6.1) | 777 (5.5) | 235 (4.5) | Ìý |
Smoking status | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 N±ð±¹±ð°ù | 65,234 (72.3) | 1133 (74.3) | 4652 (75.1) | 45,482 (71.9) | 10,209 (72.4) | 3758 (72.3) | &±ô³Ù; 0.001 |
 C³Ü°ù°ù±ð²Ô³Ù | 20,411 (22.6) | 326 (21.4) | 1284 (20.7) | 14,546 (23.0) | 3139 (22.3) | 1116 (21.5) | Ìý |
 F´Ç°ù³¾±ð°ù | 4613 (5.1) | 66 (4.3) | 261 (4.2) | 3205 (5.1) | 755 (5.4) | 326 (6.3) | Ìý |
Alcohol consumption | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 N´Ç²Ô±ð/°¿³¦³¦²¹²õ¾±´Ç²Ô²¹±ô | 75,324 (83.5) | 1326 (87.0) | 5304 (85.6) | 52,369 (82.8) | 11,867 (84.2) | 4458 (85.7) | &±ô³Ù; 0.001 |
 ≥ 1/·É±ð±ð°ì | 13,184 (14.6) | 154 (10.1) | 713 (11.5) | 9652 (15.3) | 2012 (14.3) | 653 (12.6) | Ìý |
 F´Ç°ù³¾±ð°ù | 1750 (1.9) | 45 (3.0) | 180 (2.9) | 1212 (1.9) | 224 (1.6) | 89 (1.7) | Ìý |
Fruit and Vegetable intake | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 < 3 serves/day | 27,745 (30.7) | 442 (29.0) | 1812 (29.2) | 18,865 (29.8) | 4690 (33.3) | 1936 (37.2) | &±ô³Ù; 0.001 |
 3–4 serves/day | 49,734 (55.1) | 821 (53.8) | 3342 (53.9) | 35,381 (56.0) | 7544 (53.5) | 2646 (50.9) | Ìý |
 ≥ 5 serves/day | 12,779 (14.2) | 262 (17.2) | 1043 (16.8) | 8987 (14.2) | 1869 (13.3) | 618 (11.9) | Ìý |
Baseline LTPA (MET-h/week) | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 &±ô³Ù; 1 | 4758 (5.3) | 91 (6.0) | 295 (4.8) | 3515 (5.6) | 661 (4.7) | 196 (3.8) | &±ô³Ù; 0.001 |
 1-7.49 | 56,069 (62.1) | 855 (56.1) | 3540 (57.1) | 38,101 (60.3) | 9651 (68.4) | 3922 (75.4) | Ìý |
 7.5-14.99 | 13,887 (15.4) | 233 (15.3) | 1043 (16.8) | 10,159 (16.1) | 1885 (13.4) | 567 (10.9) | Ìý |
 ≥ 15 | 15,544 (17.2) | 346 (22.7) | 1319 (21.3) | 11,458 (18.1) | 1906 (13.5) | 515 (9.9) | Ìý |
Intensity of occupational PA | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 L¾±²µ³ó³Ù | 60,828 (67.4) | 1042 (68.3) | 4091 (66.0) | 42,354 (67.0) | 9716 (68.9) | 3625 (69.7) | &±ô³Ù; 0.001 |
 M´Ç»å±ð°ù²¹³Ù±ð | 22,094 (24.5) | 360 (23.6) | 1601 (25.8) | 15,552 (24.6) | 3350 (23.8) | 1231 (23.7) | Ìý |
‽ö±ð²¹±¹²â | 7336 (8.1) | 123 (8.1) | 505 (8.2) | 5327 (8.4) | 1037 (7.4) | 344 (6.6) | Ìý |
Charlson comorbidity index | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
 0 | 17,286 (19.2) | 284 (18.6) | 1075 (17.4) | 11,875 (18.8) | 2907 (20.6) | 1145 (22.0) | &±ô³Ù; 0.001 |
 1 | 22,532 (25.0) | 382 (25.1) | 1484 (24.0) | 15,445 (24.4) | 3753 (26.6) | 1468 (28.2) | Ìý |
 ≥2 | 50,440 (55.9) | 859 (56.3) | 3638 (58.7) | 35,913 (56.8) | 7443 (52.8) | 2587 (49.8) | Ìý |
All-cause mortality | 2084 (2.3) | 57 (3.7) | 206 (3.3) | 1517 (2.4) | 220 (1.6) | 84 (1.6) | &±ô³Ù; 0.001 |
CVD-related mortality | 391 (0.4) | 12 (0.8) | 37 (0.6) | 282 (0.5) | 44 (0.3) | 16 (0.3) | 0.004 |
Follow-up years, mean (SD) | 12.1 ±â¶Ä‰1.6 | 12.0 ±â¶Ä‰1.9 | 12.0 ±â¶Ä‰1.7 | 12.2 ±â¶Ä‰1.7 | 12.0 ±â¶Ä‰1.4 | 12.0 ±â¶Ä‰1.3 | &±ô³Ù; 0.001 |