Modification of risk for all-cause and cardiovascular disease-related mortality with changes in the body mass index: a prospective cohort study with 12 years follow up

Table 3 Univariate and multivariate analysis for the association between BMI changes and the risk for CVD-related mortality

Variables	Number of participants	CVD-related mortality	Univariate	Multivariate analysis
		n (%)	HR (95%CI)	AHR (95%CI)
		n (%)	HR (95%CI)	Model 1	Model 2
BMI change	听	听	听	听	听
鈥�&濒迟;鈭�10%	1525	12 (0.8)	1.84 (1.03鈥�3.27)	2.29 (1.28鈥�4.11)	2.22 (1.24鈥�3.98)
鈥�<鈭�5% to 鈭掆€�10%	6197	37 (0.6)	1.38 (0.98鈥�1.95)	1.40 (0.99鈥�1.98)	1.33 (0.94鈥�1.89)
鈥冣垝5% to +鈥�5%	63,233	282 (0.5)	1	听	1
鈥�>+5% to <鈥�+鈥�10%	14,103	44 (0.3)	0.74 (0.54鈥�1.02)	1.09 (0.79鈥�1.50)	1.06 (0.77鈥�1.46)
鈥冣墺+10%	5200	16 (0.3)	0.77 (0.46鈥�1.27)	1.56 (0.94鈥�2.60)	1.45 (0.87鈥�2.41)
BMI group (kg/m²) at the last health screening	听	听	听	听	听
鈥僋ormal (18.5鈥�23.9)	51,457	160 (0.3)	1	听	听
鈥僓nderweight (<鈥�18.5)	8020	23 (0.3)	0.91 (0.59鈥�1.41)	2.25 (1.44鈥�3.52)	2.21 (1.41鈥�3.45)
鈥僌verweight (24鈥�26.9)	20,545	122 (0.6)	1.91 (1.51鈥�2.42)	1.25 (0.98鈥�1.59)	1.22 (0.96鈥�1.55)
鈥僌bese (鈮モ€�27)	10,236	86 (0.8)	2.70 (2.08鈥�3.51)	1.98 (1.53鈥�2.56)	1.83 (1.41鈥�2.38)

Model 1, adjusted for age (y), sex (male and female), birth cohort, and BMI status at the last health screening
Model 2, additionally adjusted for level of education, marital status, smoking status, alcohol consumption, fruit and vegetable intake, Baseline leisure time physical activity, Intensity of occupational PA, and Charlson comorbidity inde
BMI, body mass index; CVD, cardiovascular disease; AHR, adjusted hazard ratio; CI, confident interval

ISSN: 1471-2458