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Table 6 Odds ratios for more severe acute first infection symptoms among adults with a self-reported confirmed or suspected SARS-CoV-2 infection, Canada, January 2020 to August 2022 (excludes respondents with missing chronic condition diagnosis dates) (n = 9026)

From: Association between pre-existing chronic conditions and severity of first SARS-CoV-2 infection symptoms among adults living in Canada: a population-based survey analysis from January 2020 to August 2022

Characteristics

uOR

95% CI

aOR

95% CI

p value*

Pre-existing chronic conditions

ÌýÌýÌýÌýÌý

 chronic lung disease

2.39

(1.65, 3.45)

1.64

(1.08, 2.47)

0.020

 sleep apnea

1.42

(1.14, 1.76)

1.18

(0.93, 1.49)

0.180

 a²õ³Ù³ó³¾²¹

1.59

(1.30, 1.96)

1.22

(0.98, 1.52)

0.075

 chronic heart disease

1.16

(0.83, 1.64)

0.76

(0.52, 1.12)

0.166

 d¾±²¹²ú±ð³Ù±ð²õ

1.12

(0.85, 1.46)

0.89

(0.66, 1.19)

0.431

 chronic kidney disease

1.13

(0.71, 1.80)

0.96

(0.54, 1.69)

0.882

 high blood pressure

1.36

(1.17, 1.60)

1.32

(1.11, 1.58)

0.002

 chronic blood disorder

1.19

(0.59, 2.40)

0.65

(0.30, 1.43)

0.286

 o²õ³Ù±ð´Ç±è´Ç°ù´Ç²õ¾±²õ

1.08

(0.71, 1.63)

0.59

(0.39, 0.89)

0.012

 back problems

1.63

(1.37, 1.95)

1.12

(0.92, 1.38)

0.266

 urinary incontinence

1.30

(0.94, 1.80)

0.90

(0.63, 1.26)

0.525

 bowel disorder

1.68

(1.27, 2.23)

1.08

(0.82, 1.42)

0.599

 weakened immune system

2.37

(1.77, 3.16)

1.48

(1.08, 2.02)

0.014

 chronic neurological disorder

1.71

(1.09, 2.70)

0.93

(0.59, 1.48)

0.760

 chronic fatigue syndrome or fibromyalgia

4.57

(3.00, 6.97)

2.12

(1.34, 3.36)

0.001

 s³Ù°ù´Ç°ì±ð

1.06

(0.58, 1.94)

0.78

(0.40, 1.51)

0.454

 mental health condition

1.64

(1.39, 1.94)

1.10

(0.91, 1.32)

0.326

 a°ù³Ù³ó°ù¾±³Ù¾±²õ

1.70

(1.44, 2.00)

1.24

(1.01, 1.52)

0.044

Age at infection (ref = 15–34)

-

-

-

-

&±ô³Ù; 0.001

 35–49

1.02

(0.90, 1.16)

1.04

(0.91, 1.19)

0.559

 50–64

1.10

(0.96, 1.26)

0.96

(0.83, 1.12)

0.628

 65+

0.87

(0.74, 1.02)

0.67

(0.55, 0.83)

&±ô³Ù; 0.001

Sex (ref = male)

-

-

-

-

&±ô³Ù; 0.001

 f±ð³¾²¹±ô±ð

1.44

(1.29, 1.60)

1.31

(1.16, 1.47)

&±ô³Ù; 0.001

Ethnicity (ref = white)

-

-

-

-

0.023

 I²Ô»å¾±²µ±ð²Ô´Ç³Ü²õ

1.26

(0.97, 1.64)

1.14

(0.87, 1.50)

0.338

 South Asian

0.97

(0.71, 1.32)

0.93

(0.66, 1.29)

0.648

 East/Southeast Asian

0.64

(0.51, 0.80)

0.62

(0.49, 0.79)

&±ô³Ù; 0.001

 B±ô²¹³¦°ì

0.90

(0.57, 1.44)

0.81

(0.50, 1.32)

0.400

 Arab/West Asian

0.73

(0.48, 1.10)

0.72

(0.46, 1.13)

0.152

 Latin American

0.87

(0.56, 1.34)

0.89

(0.57, 1.37)

0.582

 M¾±³æ±ð»å/°¿³Ù³ó±ð°ù

1.09

(0.80, 1.47)

1.09

(0.79, 1.51)

0.597

Ethno-cultural composition (ref = first quintile)a

-

-

-

-

0.002

 s±ð³¦´Ç²Ô»å

1.27

(1.07, 1.51)

1.25

(1.04, 1.51)

0.016

 t³ó¾±°ù»å

1.21

(1.03, 1.42)

1.19

(1.00, 1.42)

0.052

 f´Ç³Ü°ù³Ù³ó

1.40

(1.19, 1.64)

1.43

(1.20, 1.70)

&±ô³Ù; 0.001

 fifth (highest)

1.20

(0.99, 1.44)

1.39

(1.13, 1.71)

0.002

 u²Ô°ì²Ô´Ç·É²Ô

1.37

(1.11, 1.70)

1.44

(1.12, 1.87)

0.005

Situational vulnerability (ref = first quintile)b

-

-

-

-

0.001

 s±ð³¦´Ç²Ô»å

0.96

(0.82, 1.13)

0.97

(0.82, 1.15)

0.716

 t³ó¾±°ù»å

1.02

(0.87, 1.19)

0.95

(0.80, 1.12)

0.517

 f´Ç³Ü°ù³Ù³ó

1.06

(0.90, 1.25)

0.98

(0.82, 1.17)

0.851

 fifth (highest)

0.78

(0.65, 0.93)

0.68

(0.56, 0.82)

&±ô³Ù; 0.001

 u²Ô°ì²Ô´Ç·É²Ôc

1.09

(0.89, 1.33)

-

-

-

Pre-existing chronic health symptoms

ÌýÌýÌýÌýÌý

 symptoms relating to the heart

1.94

(1.53, 2.47)

1.33

(1.01, 1.75)

0.039

 loss of appetite

3.08

(1.94, 4.89)

1.80

(1.11, 2.92)

0.017

Number of pre-existing chronic health symptoms (ref = 0)

-

-

-

-

&±ô³Ù; 0.001

 1 or 2

1.29

(1.11, 1.47)

1.21

(1.06, 1.39)

0.005

 3

1.74

(1.43, 2.11)

1.64

(1.33, 2.03)

&±ô³Ù; 0.001

 &²µ³Ù; 3

2.21

(1.92, 2.54)

1.60

(1.32, 1.93)

&±ô³Ù; 0.001

Months since last vaccine dose prior to the month of infection (ref = 3 months or less)

-

-

-

-

&±ô³Ù; 0.001

 not vaccinated

1.96

(1.67, 2.30)

1.49

(1.14, 1.93)

0.003

 4–6 months

1.23

(1.08, 1.40)

1.33

(1.16, 1.51)

&±ô³Ù; 0.001

 > 6 months

1.22

(1.02, 1.46)

1.28

(1.06, 1.54)

0.009

 u²Ô°ì²Ô´Ç·É²Ô

1.11

(0.76, 1.61)

1.04

(0.72, 1.50)

0.822

Time period of first infection (ref = pre-omicron)

-

-

-

-

0.004

 Omicron (December 1, 2021 – date of electronic questionnaire completion)

0.57

(0.50, 0.66)

0.67

(0.53, 0.87)

0.002

 u²Ô°ì²Ô´Ç·É²Ô

1.14

(0.42, 3.11)

1.48

(0.50, 4.37)

0.482

Household member testing positive for SARS-CoV-2 infection (ref = no)

-

-

-

-

0.001

 y±ð²õ

0.76

(0.68, 0.85)

0.84

(0.74, 0.94)

0.004

 u²Ô°ì²Ô´Ç·É²Ô

1.42

(0.73, 2.77)

1.77

(0.90, 3.49)

0.099

  1. Notes: Estimates for Canada exclude the territories. All estimates are weighted. The reference category for a pre-existing chronic condition or symptom are adults without the chronic condition or symptom, respectively
  2. Abbreviations: aOR = adjusted odds ratio, CI = confidence interval, n = unweighted number of respondents included in the final model, ref = reference, uOR = unadjusted odds ratio
  3. *p value is only for the fully adjusted model
  4. a Ethno-cultural composition quantifies a neighbourhood’s makeup of immigrant populations
  5. b Situational vulnerability quantifies a neighbourhood’s education level, Indigenous composition, and extent of dwellings in need of major repairs
  6. c For the dimensions of deprivation, values for an individual were either known or unknown for all dimensions. Consequently, the parameter for unknown situational vulnerability has a value of 0 in the final adjusted model because it is a linear combination of the parameter for unknown ethnocultural composition